Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 23;12(4):387. doi: 10.3390/pharmaceutics12040387

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of pH on CIP aqueous solubility calculated using the following equation: $S = S_{0} (1 + 10^{(p k a_{1} - p H)} + 10^{(p H - p k a_{2})})$ , with pka₁ = 6.2, pka₂ = 8.6 [20,75]. Individual values are from Yu et al. [76] (empty triangles); McShane et al. [20] (plain dot); Blokhina et al. [77] (empty diamond; Roca Jalil et al. [78] (square). Values were measured between 25 and 30 °C.