Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The relationship between the affinity of the complex formed between CIP and the metal cation and pulmonary exposure to CIP after IT administration of the complex.
| (CIP–Ca)2+ | (CIP–Cu)2+ | CIP solution | |
|---|---|---|---|
| Ka (M−1) (from [31]) | 100 | 906,900 | |
| Concentration (µM) needed to reduce the CIP Papp by 50% (from [31]) | 40 | 0.04 | |
| ELF Cmax (µg/mL) after IT administration to rats (from [22]) | 26.5 ± 17.7 | 142.3 ± 81.5 | 1.0 ± 0.4 |
| CIP AUCELF to AUCplasma ratio after IT administration to rats (from [22]) | 203 | 1069 | 9.8 |
