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. 2020 Apr 16;9(4):294. doi: 10.3390/pathogens9040294

Figure 1.

Figure 1

Schematic of the chicken anemia virus (CAV) Vp3 protein, apoptin. A leucine-rich nuclear export signal (NES) is identified (blue) in the N-terminus from amino acids 33–46, and a bipartite nuclear localization signal (NLS) is pictured (green) in the C-terminus from amino acids 82–88 and 111–121. A region from amino acids 1–48 containing a multimerization domain and sequences in the NES that are important for targeting to promyelocytic leukemia (PML) bodies are indicated with brackets. The APC1 binding domain from amino acids 82–121 in the C-terminus is also shown. Threonine residues at positions 56, 61, 107, and 108 are labelled (red) as important phosphorylation sites for regulation.