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The structure of the inflammasome. (a) NOD-like receptor protein 3 (NLRP3) inflammasome, (b) NLR-family CARD domain-containing protein 4 (NLRC4) inflammasome, (c) Absent in melanoma 2 (AIM2) inflammasome. The inflammasome structure is composed of functional units such as a leucine-rich repeat (LRR) C-terminal or DNA-binding domain (HIN200), a nucleotide binding domain (NBD), a pyrin domain (PYD), and a caspase recruitment domain (CARD).
