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. 2020 Apr 17;12(4):366. doi: 10.3390/pharmaceutics12040366

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Representative Haemotoxylin & Eosin stained histology sections of the ear after DMN patch application. The left column shows ear sections after 120 min of DMN patch application. The right column represents the patch application site (the rectangular sub-sections shown in the left column) (A,B) DMN patch containing maximal dose (331.20 μg) of lidocaine-HCl (C,D) DMN patch containing a half-maximal dose (165.60 μg) of lidocaine-HCl (E,F) DMN patch containing a quarter maximal dose (82.80 μg) of lidocaine-HCl (G,H). Blank DMN patch without lidocaine-HCl. Red arrows indicate DMN insertion sites. Scale bar indicates 100 μm and 20 μm in the left and the right column, respectively.