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Hot-melt extrusion process parameters for the drug-containing amorphous solid dispersions (ASDs) including drug content.
| Composition | HME Conditions | Content (Assay) (%) |
||
|---|---|---|---|---|
| Temperature (°C) |
Feed Rate (%) |
Torque (%) |
||
| IND/PEG3000/PVAP 10/10/80 |
120 | 1 | 49.3 | 99.5 ± 3.21 |
| 120 | 2 | 60.0 | 99.3 ± 1.13 | |
| 120 | 3 | 66.7 | 104.2 ± 0.04 | |
| DPD/PEG3000/PVAP 10/10/80 |
120 | 1 | 50.0 | 0.85 ± 0.01 |
| 120 | 2 | 56.6 | 4.3 ± 0.01 | |
| 120 | 3 | 66.7 | 7.5 ± 0.12 | |
