Skip to main content
. 2020 Mar 27;12(4):304. doi: 10.3390/pharmaceutics12040304

Figure 1.

Figure 1

(A) Macroscopic analysis of the oral mucosa of hamsters (golden sirian) with oral mucositis (OM) induced by 5-fluorouracil (5-FU) and mechanical trauma (MT). PVP group: Animals with healthy, no erosion or vasodilatation of the oral mucosa, these hamsters only received PVP solution via i.p. (It is appropriate) or 10 days (a). Mechanical trauma (MT) group: Animals submitted to excoriation on the 10th day of the experimental model, the oral mucosa showed vasodilation and erythema (b). The 5-FU group: Animals that developed OM by administering 5-FU (IP) and mechanical trauma, the group showed oral mucositis characterized by ulcer formation, severe erythema, and vasodilation (c). The groups with OM treated with AuNp 62.5 (d), 125 (e), or 250 µg/kg (IP) (f). The animals treated with AuNp 250 µg/kg had mild vasodilation and superficial erosion in the oral mucosa, with no evidence of ulcers. (B) Score graph with the standard error of the mean (n = 5/group). ** p < 0.001; *** p < 0.0001 (Kruskal–Wallis test and Dunn’s multiple comparison test).