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. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: J Am Chem Soc. 2020 Apr 21;142(17):7783–7794. doi: 10.1021/jacs.9b13813

Figure 1.

Figure 1.

Schematic showing the dispersion of AcetalDextran-AuNPs from micelles when placed in an acidic environment. Ultrasmall gold particles are coated with a hydrophobic pH-sensitive polymer, acetalated dextran; upon exposure to low pH environments, this hydrophobic coating becomes hydrophilic. Polymeric micelles encapsulating these materials will be stable at standard physiological pH but will dissociate within the lysosome, allowing dispersion of soluble AuNPs.