Skip to main content
. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: J Am Chem Soc. 2020 Apr 21;142(17):7783–7794. doi: 10.1021/jacs.9b13813

Figure 6.

Figure 6.

In vivo pharmacokinetics and biodistribution of ADAMs. Mice were injected intravenously with 100 mg Au per kg body weight, and samples were collected at various timepoints post-injection (n = 3 mice per timepoint, expressed as average ± SEM). (a) Blood samples were analyzed by ICP-OES to determine gold content; curve-fitting was performed using MATLAB software. (b) Tissue and fluid samples were analyzed by ICP-OES to determine gold content (n = 3 mice per timepoint, expressed as average ± SEM.) Note that feces and urine values represent samples collected on the day of sacrifice, and do not represent the cumulative excretions between timepoints. Statistical comparison was performed using one-way ANOVA with post-hoc Tukey HSD test; *p < 0.05 relative to measurement at 1 day. (c) Urine was collected at 24 hours post-injection, diluted 1:1 in pure water, and imaged by electron microscopy. Electron-dense 2-nm particles are consistent with the appearance of Dextran-AuNPs.