Table 1.

Physiochemical parameters for AcetalDextran-AuNP-Micelles and precursor gold nanoparticles.

	% Au [w/w]a	Core diameterb	Hydrodynamic diameterc	Solubilityd	pH sensitivitye
pMBA-AuNPs	79.3%	1.7 ± 0.5 nm	5.0 nm PDI: 0.251	Water	No
Dextran-AuNPs	31.0%	2.1 ± 0.5 nm	7.3 nm PDI: 0.246	Water, DMSO	No
AcetalDextran-AuNPs	13.8%	2.1 ± 0.6 nm	n/a	Acetone, Toluene, Chloroform	Yes
AcetalDextran-AuNP-Micelles	11.4%	111.1 ± 38 nm	146.0 nm PDI: 0.156	Water	Yes

^aPercent gold mass measured by ICP-OES.

^bCore diameters measured by transmission electron microscopy, expressed as the average of 40–100 particle measurements, ± standard deviation.

^cHydrodynamic diameters measured by dynamic light scattering, expressed as the mean intensity and polydispersity index averaged for three measurements (pMBA-AuNPs and Dextran-AuNPs, one batch; AcetalDextran-AuNP-Micelles, six batches).

^dSolubility is not comprehensive.

^epH sensitivity refers to observed changes in particle solubility and sedimentation behavior after incubation at pH 5.0.