Figure 1.

Experimental design and SAH induction. (a) Schematic representation of the experimental design for both SAH and sham-operated animals. Neurovascular coupling and endothelium-dependent response were assessed one month after the surgical procedure. (b) Cerebral blood flow and (c) intracranial pressure recordings starting 5 min before SAH or sham-operated induction and continuing for subsequent 15 min. A sudden decrease in CBF and sharp increase in ICP confirms SAH inductions. Mean ± SD; n = 10 in sham and n = 9 in SAH group.