Figure 3.

Temporal response to intermittent 24-s BH challenges in a patient with OSA (AHI = 28) and BOLD-derived BH indices. (a) BOLD signal (%) averaged across the whole brain, gray matter and white matter; (c) tCBF (mL/min/100 g brain) and SSS flow velocity (cm/s). (b, d) Temporal averages of time-course data in (a, c), with dashed lines representing calculated slopes yielding BHI. Shaded area represents apneic period. (e) BHI maps derived from BOLD for three imaging slices from the same OSA patient and a representative NSA subject. (f) BHI for OSA subjects (red) and NSA reference subjects (green) pertaining to whole brain, GM, and WM. Greater BH indices in OSA were significant in all three brain regions.