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. 2019 Jul 11;40(6):1300–1315. doi: 10.1177/0271678X19858637

Figure 3.

Figure 3.

Ischemic stroke alter brain gene (mRNA) expression. (a) Principal Coordinate Analysis (PCoA) of mouse brain transcriptomes (n = 5). InoR: Ischemia no reperfusion (blue); IR: ischemia-reperfusion (red); and sham control (green). NMDS: Non-metric multidimensional Scaling. (b, c) Volcano plots of significant differentially expressed mRNAs. Red, significantly increased; Blue, significantly decreased miRNAs (≥1.5- absolute fold change, Benjamini–Hochberg-corrected p < 0.05; n = 5). Presented as Log2 fold change vs. −Log10 corrected p-values. (b) InoR/Sham (n = 5). (c) IR/Sham (n = 5). (d) Venn diagram of overlapping gene (mRNA) expression changes in response to sustained (InoR) and transient (IR) ischemia in the brain.