Figure 5.

Stroke induces macrophage infiltration into heart which persists from acute to chronic phase of stroke. (a) CD45 immunostaining and quantification data indicate that stroke significantly increases CD45 + cells in heart at three days and one month after stroke compared to sham control and splenectomy only group, respectively. F value=8.61. (b) IBA-1 immunostaining and quantification data indicate that stroke significantly increases IBA-1 positive macrophages in heart at three days as well as one month after stroke compared to sham control mice. Splenectomy with stroke significantly decreases IBA-1 positive macrophages at three days after stroke. F value=6.25. Sample size: Control n = 5, 3d-spx=4, 3d-stroke n = 5, 3d-spx-stroke n = 5, 1m-spx n = 5, 1m-stroke n = 5, 1m-spx-stroke=4. *p < 0.05, One-way ANOVA (Tukey).