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. 2019 Jul 29;40(6):1338–1350. doi: 10.1177/0271678X19865917

Figure 4.

Figure 4.

Transduction of endothelial cells with AAV-BR1-CAG-HEXA/B reduces astrocytic activation in Hexb−/− mice. (a) GFAP immunostaining of brain sections from Hexb+/+ and Hexb−/− mice which were treated either with the vectors AAV-BR1-CAG-HEXA/B or AAV-BR1-CAG-Ø at the age of 25–30 days and were sacrificed at the age of 85–95 days indicated that endothelial HEXA/B expression blunted astrocytic activation in different brain regions. (b) Quantification of astrocytic activation by counting GFAP-positive cells in different brain regions. Data are means ± SD analyzed by one-way ANOVA (cortex, F(2/29) = 28.02, p < 0.0001; striatum, F(2/29) = 29.55, p < 0.0001; cerebellum, F(2/23) = 11.08, p < 0.0005), *p < 0.05, ***p < 0.0001 (Bonferroni test, n = 5 mice per group).