Table I.

Mutation occurrence of genes in CRC.

A, Driver genes
	0.5% as cutoff		5% as cutoff
Gene	Positive cases	Positive rate, %	Positive cases	Positive rate, %
KRAS	61	52.1	50	42.7
KIT	23	19.7	11	9.4
PIK3CA	35	29.9	19	16.2
MET	18	15.4	10	8.5
EGFR	17	14.5	1	0.9
BRAF	14	12	6	5.1
IDH1	14	12	1	0.9
PDGFR3	10	8.5	0	0
CTNNB1	8	6.8	5	4.2
IDH2	8	6.8	0	0
HER2	6	5.1	1	0.9
SMO	6	5.1	1	0.9
B, Tumor suppressor genes
	0.5% as cutoff		5% as cutoff
Gene	Positive cases	Positive rate, %	Positive cases	Positive rate, %
TP53	77	65.8	56	47.9
APC	46	39.3	34	29.1
CDKN2A	38	32.5	1	0.9
STK11	23	19.7	11	9.4
FBXW7	23	19.7	8	6.8
PTEN	19	16.2	2	1.7
SMAD4	14	12	3	2.6
MLH1	12	10.3	7	6
VHL	10	8.5	2	1.7
ATM	9	7.7	2	1.7
RB1	7	6	0	0
HNF1A	7	6	0	0
SMARCB1	6	5.1	2	1.7