Table III.

Spectrum of mutations in driver genes.

Gene	Exon	Mutations	Positive cases, n	Relative frequencyaa (%)
BRAF	exon15	p.V600E/M	6	40
		Others	9	60
EGFR	Exon19	p.A743T	5	22.7
	Exon18	p.G721S	4	18.2
	Exon19	p.746del	3	13.6
		Others	10	45.5
IDH1	Exon4	p.R132C/Hb	13	86.7
		Others	2	13.3
KIT	Exon10	p.M541Lb	19	79.2
		Others	5	20.8
KRAS	Exon2	p.G12A/C/D/S/Vb	41	61.2
	Exon2	p.G13D	13	19.4
	Exon4	p.A146T	5	7.5
	Exon2/3	Others	8	11.9
MET	Exon2	p.N375Sb	17	94.4
	Exon14	p.R988C	1	5.6
PIK3CA	Exon10	p.E545G/K	12	27.9
	Exon21	p.H1047L/R	8	18.6
	Exon21	p.R1023Q	8	18.6
	Exon2	p.R88Q	6	14
		Others	9	20.9

^aRelative to total number of mutations in the same gene;

^bHotspot mutation.