| Step | Problem | Possible reason | Possible solution |
|---|---|---|---|
| 1 | TALOS+ predictions are not classified as “Good” | Chemical shift may be not calibrated; chemical shift assignments may be too incomplete | Calibrate the chemical shifts against DSS; acquire additional NMR spectra to improve the chemical shift assignments |
| 6 | More than one solution is found | The number of inter-NOEs may be insufficient | Improve the NOESY assignment. |
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