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IC50 values for 1 and 3 with c-Src varied homologous kinases.
| kinase | 1 IC50 (μM) | 3 IC50 (μM) |
|---|---|---|
| Hck | 8.9 | 2.8 ± 0.7 |
| Lck | 9.3 | 5.3 ± 0.6 |
| Blk | 21.8 | 5.3 ± 0.7 |
| Frk | 9.6 | 5.6 ± 0.4 |
| Fyn1 | 2.8 | 0.27 ± 0.02 |
| Fgr | 4.6 | 3.1 ± 0.9 |
| Lyn | 10.8 | 2.5 ± 0.2 |
| Abl | 15.0 | 4.0 ± 0.4 |
