Table 1.
Presentation and outcomes in patients diagnosed between 2010 and 2018 with IDH-mut astrocytomas (N = 50), presented in relation to the T2-FLAIR mismatch sign presence or absence
| Mismatch (N = 12, 24.0%) | No mismatch (N = 38, 76.0%) | P-value | |
|---|---|---|---|
| Age, years, mean (SD) | 35.7 (12.6) | 41.9 (14.4) | 0.06 |
| Female, n (%) | 7 (58.3) | 16 (42.1) | 0.51 |
| Main lobe involved, n (%) | |||
| Frontal | 7 (58.3) | 17 (44.7) | 0.51 |
| Temporal | 3 (25.0) | 13 (34.2) | 0.73 |
| Parietal | 2 (16.7) | 7 (18.4) | 1.00 |
| Insula | 0 (0.0) | 1 (2.6) | 1.00 |
| Image findings, n (%) | |||
| Right side | 6 (50.0) | 15 (39.5) | 0.74 |
| Left side | 6 (50.0) | 23 (60.5) | 0.74 |
| Bilateral/midline | 0 (0.0) | 5 (13.2) | 0.32 |
| Conspicuous border | 9 (75.0) | 12 (31.6) | 0.02 |
| Eloquence | 8 (66.7) | 30 (78.9) | 0.45 |
| Symptom at diagnosisa, n (%) | |||
| Asymptomatic | 0 (0.0) | 3 (7.9) | 1.00 |
| Seizure | 9 (75.0) | 28 (73.7) | 1.00 |
| ICP related | 3 (25.0) | 11 (28.9) | 1.00 |
| Deficit(s) | 0 (0.0) | 5 (13.2) | 0.32 |
| Language deficit | 2 (16.7) | 2 (5.3) | 0.24 |
| Visual deficit | 2 (16.7) | 4 (10.5) | 0.62 |
| Cognitive changes | 3 (25.0) | 8 (21.1) | 1.00 |
| Other symptoms | 1 (8.3) | 10 (26.3) | 0.25 |
| Type of surgery, n (%) | |||
| Resection | 11 (91.7) | 37 (97.4) | 0.43 |
| Volumetric measurements | |||
| Preoperative volume, ml, median (Q1-Q3) | 47.4 (29.71–113.61) N = 11 | 63.3 (26.52–115.32) N = 37 | 0.91 |
| Postoperative volume, ml, median (Q1-Q3) | 5.9 (1.67–14.81) N = 11 | 5.0 (0.34–16.42) N = 37 | 0.99 |
| Extent of resection, median % (Q1-Q3) | 87.9 (73.60–96.63) N = 11 | 89.2 (48.50–99.75) N = 37 | 0.91 |
| WHO grade, n (%) | |||
| WHO grade II | 5 (41.7) | 24 (63.2) | 0.31 |
| WHO grade III | 6 (50.0) | 13 (34.2) | 0.50 |
| WHO grade IV | 1 (8.3) | 1 (2.6) | 0.43 |
aMore than one symptom at presentation possible. Other symptoms included paresthesia, vertigo, dysphagia, among others