Table 2.
Interactions between NCL proteins in mammals
| Protein 1 | Protein 2 | Effect | Sample | Reference |
|---|---|---|---|---|
| PPT1/CLN1 | CTSD/CLN10 | Interaction | SH-SY5Y human neuroblastoma cells | Scifo et al., 2013 [59] |
| CLN5 | TPP1/CLN2 | Interaction | COS-1 cells | Vesa et al., 2002 [77] |
| CLN3 | ||||
| CLN5 | PPT1/CLN1 | Interaction | Mouse brain extract COS-1 cells (author note: place on a separate line under "Mouse brain extract") HeLa cells (author note: place on a separate line under "COS-1 cells") | Lyly et al., 2009 [78] |
| TPP1/CLN2 | ||||
| CLN3 | ||||
| CLN6 | ||||
| CLN8 | ||||
| CTSD/CLN10 | PGRN/CLN11 | Interaction | HEK293T cells | Zhou et al., 2017; Valdez et al., 2017 [79, 80] |
| PPT1/CLN1 | DNAJC5/CLN4 | PPT1/CLN1 depalmitoylates DNAJC5/CLN4 | PPT1/CLN1 from HEK293T cell media depalmitoylated DNAJC5/CLN4 isolated from mouse brain | Henderson et al., 2016 [81] |
| PPT1/CLN1 | CLN5 | PPT1/CLN1 regulates the trafficking of CLN5 | HeLa cells | Lyly et al., 2009 [78] |
| CLN3 | CTSD/CLN10 | Co-localization under hypertonic conditions | Baby hamster kidney cells | Cárcel-Trullols et al., 2017 [82] |
| Increased expression of CLN3 under hypertonic conditions | CTSD/CLN10 | Decreased activity of CTSD/CLN10 | Baby hamster kidney cells | Cárcel-Trullols et al., 2017 [82] |
| CLN5 | CTSD/CLN10 | CLN5 regulates the processing of CTSD/CLN10 | CLN5 (N320S) expressed in HeLa cells reduced the processing of CTSD/CLN10 to its enzymatically active form | Qureshi et al., 2018 [83] |
| PGRN/CLN11 | CTSD/CLN10 | PGRN/CLN11 increases the activity of CTSD/CLN10 | Human PGRN and CTSD/CLN10 from bovine spleen | Valdez et al., 2017 [80] |