Table 1.

Role of METTL3 in gastrointestinal cancer

Cancer type	Role of METTL3	Target	Biological function	Mechanism	Upstream	Reader	Ref
GC	Oncogene	HDGF	Promotes cell proliferation, invasion, and migration, tumor growth, angiogenesis, liver metastasis, glycolysis	Enhance HDGF mRNA stability	H3K27ac	IGF2BP3	[33]
	Oncogene	LINC00470	Promotes cell proliferation, invasion, and migration	Interacts with LINC00470 to suppress PTEN stability	No study	YTHDF2	[34]
	Oncogene	ZMYM1	Promotes EMT process and metastasis	Enhance ZMYM1 mRNA stability	No study	ELAVL1	[35]
	Oncogene	SEC62	Promotes cell proliferation and inhibits apoptosis	Enhance SEC62 mRNA stability	MiR-4429	IGF2BP1	[36]
	Oncogene	EMT markers	Promotes cell proliferation, invasion, and migration	Promotes EMT process	Transcription factor GFI- 1	No study	[37]
	Oncogene	ARHGAP5-AS1	Promotes chemoresistance	Stimulates m6A of ARHGAP5 mRNA to enhance ARHGAP5-AS1 stability	ARHGAP5-AS1	No study	[38]
	Oncogene	AKT pathway, apoptosis pathway	Promotes cell proliferation, migration, and invasion	Activates AKT and decreases apoptosis pathway	No study	No study	[39]
	Oncogene	MYC	Promotes cell proliferation, migration, and invasion	Activates MYC	No study	No study	[40]
CRC	Oncogene	miR-1246	Promotes cell migration, invasion and metastasis	Promotes the maturation of pri-miR-1246	No study	No study	[41]
	Tumor suppressor	p-p38 and p-ERK	Inhibits proliferation, migration, and invasion	Inhibits p-p38 and p-ERK pathway	No study	No study	[42]
	Oncogene	SOX2	Promotes self-renewal, stem cell frequency, migration, and tumorigenesis and metastasis	Prevents SOX2 mRNA degradation	No study	IGF2BP2	[43]
	Oncogene	P53	Acquires multidrug resistance	Promotes pre-mRNA splicing	No study	No study	[44]
	Oncogene	CCNE1	Promotes cell proliferation	stabilizes CCNE1 mRNA	No study	No study	[45]
	Oncogene	HK2 and GLUT1	Promotes glycolysis and tumorigenesis.	Stabilized HK2 and GLUT1 mRNA	No study	IGF2BP2/3	[46]
LC	Oncogene	miR6079	accelerates progression of liver cancer cells	Promotes miR6079 expression	miR24-2	No study	[47]
	Oncogene	LINC00958	Promotes HCC cell proliferation, motility, lipogenesis, and tumor growth, metastasis	Promotes LINC00958 RNA transcript stability	No study	No study	[48]
	Oncogene	Snail	Promotes HCC migration, invasion and EMT of cancer cells both in vitro and in vivo.	Triggers polysome-mediated translation of Snail mRNA	No study	YTHDF1	[49]
	Oncogene	SOCS2	Promotes HCC proliferation, migration, colony formation, tumorigenicity, and lung metastasis	Reduces SOCS2 mRNA expression	No study	YTHDF2	[50]
	Oncogene	mTORC1	Promotes HCC glycolysis	Increases mTORC1 activity	No study	No study	[51]
PC	Oncogene	Unspecific	Promotes proliferation, invasion, and migration	No study	No study	No study	[52]
	Oncogene	miR-25-3p	Promotes tumorigenesis	Promote miR-25 processing and maturation	Hypomethylation	No study	[53]
	Oncogene	MAPK, ubiquitin, and RNA splicing	Promotes chemo- and radioresistance	Activates MAPK, ubiquitin, and RNA splicing pathway	No study	No study	[54]

GC gastric cancer, CRC colorectal cancer, LC liver cancer, HCC hepatocellular carcinoma, PC pancreatic cancer