Table 5.
Sensitivity, specificity, PPV, NPV, accuracy, unnecessary surgical exploration rate and inappropriately unexplored rate of different cut-off values used in ROC analysis by the number of 18F-FDG avid peritoneal sites
| No. of 18F-FDG avid peritoneal sites a | True Positive | False Positive | False Negative | True Negative | Sensitivity | Specificity | PPV | NPV | Accuracy | Unnecessary surgical exploration b | Inappropriately unexplored c |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ≥ 0 | 11 | 38 | 0 | 0 | 100.0% | 0.0% | 22.4% | – | 22.4% | – | 77.6% |
| ≥ 1 | 10 | 18 | 1 | 20 | 90.9% | 52.6% | 35.7% | 95.2% | 61.2% | 4.8% | 64.3% |
| ≥ 2 | 6 | 4 | 5 | 34 | 54.5% | 89.5% | 60.0% | 87.2% | 81.6% | 12.8% | 40.0% |
| ≥ 3 | 4 | 1 | 7 | 37 | 36.4% | 97.4% | 80.0% | 84.1% | 83.7% | 15.9% | 20.0% |
| ≥ 4 | 4 | 0 | 7 | 38 | 36.4% | 100.0% | 100.0% | 84.4% | 85.7% | 15.6% | 0.0% |
| ≥ 5 | 1 | 0 | 10 | 38 | 9.1% | 100.0% | 100.0% | 79.2% | 79.6% | 20.8% | 0.0% |
| ≥ 6 | 0 | 0 | 11 | 38 | 0.0% | 100.0% | – | 77.6% | 77.6% | 22.4% | – |
Remarks:
aFifteen anatomical sites were scrutinized for the presence of peritoneal carcinomatosis (right subphrenic, right subhepatic, gastric, lesser sac, left subphrenic, left perihepatic, right paracolic, left paracolic, POD, bladder flap, mesentery, omentum, large bowel serosa, small bowel serosa and pelvis regions)
bUnnecessary surgical exploration (%): the ratio of patients thought to have resectable disease but who will turn out to have incomplete debulking after surgery; correspond to false negative rate (1 - NPV)
cInappropriately unexplored (%): the ratio of patients thought to have unresectable disease but who will turn out to have complete debulking after surgery; correspond to false positive rate (1 - PPV)