Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 24;53(6):564–576. doi: 10.1177/0023677218824382

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 5. — Representative sections of retrobulbar sinus-injected mice. The histological sections were stained with hematoxylin and eosin. (a) An overview of the intraorbital tissues, including the bulbus and the Harderian gland. For four of the five mice, no pathological changes were observed five days after the injection of a physiological saline solution. (b), (c) and (d) Lesions of varied severity five days after the injection of doxorubicin. (b) Focal mild inflammatory infiltration of lymphocytes and plasma cells in the retrobulbar connective tissue (▸). (c) The replacement of multiple degenerated orbital muscle fibres from severe proliferation of the granulation tissue (★). (d) The severe proliferation of granulation tissue and cell infiltration with neutrophilic granulocytes, macrophages, lymphocytes and plasma cells in the temporal muscle (★) adjacent to the orbital bone and retrobulbar sinus. Within the granulation tissue are several separated degenerated myofibers (▸). (e), (f) Examples of commonly detected lesions in mice 25 days after doxorubicin injection: (e) The medial part of the Harderian gland shows marked interstitial fibrosis and loss of multiple acini (★) between the bulbus (left) and orbital bone (right); (f) a closer view of the changes, besides fibrosis, in the Harderian gland: with prominent extracellular collagenous matrix (★) and loss of acini, as well as mild acinar regeneration (▸). Scale bars: (a) 500 µm; (b), (c), (e) 100 µm; (d), (f) 50 µm.