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. 2020 May 20;11:188. doi: 10.1186/s13287-020-01686-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Identification of miR-205-5p as a negatively pathologic miRNA in endometriosis. a The different miRNA expression profiles between the EN (n = 3) and EC (n = 3) groups were analysed by miRNA microarray. The heatmap diagram shows that the representative miRNAs were significantly associated with endometriosis. EN1, EN2, and EN3 indicate 3 normal endometria; EC1, EC2, and EC3 indicate 3 ectopic endometria. b The levels of 16 differentially expressed miRNAs in the endometrium used for microarray analysis were analysed by qRT-PCR. c, d The levels of miR-205-5p, miR-4497, miR-3154, and miR-3926 were validated by qRT-PCR in additional tissues and serum from the EN (n = 23) and EC (n = 68) groups. EN, normal endometrium; EC, ectopic endometrium. Error bars represent the mean ± SD of 3 independent experiments. n.s., not significant; *P < 0.05; **P < 0.01; ***P < 0.001