Figure 7.

Spontaneous thalamocortical network oscillations from KI mice were longer and more frequent than those from wild type littermate mice. Representative extracellular multiple unit recordings from VBn in slices showing (A) spontaneous brief thalamocortical bursts in wild-type mice and (B) spontaneous prolonged thalamocortical oscillations in KI mice. One short burst from a wild type and one oscillation from a KI mouse were expanded in each panel to show the multiple spikes in the burst or oscillation. Scale bars are as indicated. (C) Average duration of spontaneous bursts for P42 wild-type mice (0.78 ± 0.71 s, n = 6 mice) and spontaneous oscillations from P42 KI mice (6.88 ± 1.39 s, n = 9 mice) were plotted (**P < 0.01, Student’s t-test). VBn: thalamic ventrobasal nucleus.