Table 3.

Parameters of the distal femoral metaphysis by CT imaging and histomorphometric analysis.

	Control (n = 8)	Vehicle (n = 8)	SBI-10 (n = 8)	SBI-30 (n = 8)
Ct. BMD (mg/cm3)	1077.5 ± 10.4	577.4 ± 24.9**	590.4 ± 18.5**	629.9 ± 12.9**
BMD (mg/cm3)	452.2 ± 20.7	322.8 ± 22.4**	285.9 ± 8.9**	299.3 ± 13.1**
Ct. BMC (mg)	0.95 ± 0.03	0.43 ± 0.02**	0.48 ± 0.01**	0.49 ± 0.01**
BMC (mg)	1.77 ± 0.15	1.06 ± 0.10**	1.19 ± 0.06**	1.22 ± 0.08**
Ct. B. Th (mm x10−1)	10.65 ± 0.16	9.08 ± 0.10**	8.78 ± 0.05**	8.83 ± 0.02**
BV/TV (%)	12.14 ± 1.11	8.57 ± 1.29**	7.74 ± 1.41**	7.57 ± 1.14**
Tb.Th (μm)	36.45 ± 1.92	35.92 ± 1.01	35.81 ± 1.52	37.47 ± 1.50
Tb.N (N/mm)	3.32 ± 0.16	2.39 ± 0.34**	2.13 ± 0.30**	2.01 ± 0.28**
ES/BS (%)	2.06 ± 0.46	14.31 ± 3.89**	13.19 ± 2.34**	15.87 ± 1.14**
Oc.S/BS (%)	0.83 ± 0.22	8.44 ± 2.67**	8.03 ± 2.16**	9.88 ± 1.32**
MAR (μm/day)	1.00 ± 0.22	0.81 ± 0.10	1.26 ± 0.03	1.17 ± 0.13

Ct. BMD, cortical bone mineral density; BMD, bone mineral density; Ct. BMC, cortical bone mineral content; BMC, bone mineral content; Ct. B. Th, Cortical bone thickness; BV/TV, bone volume per tissue volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; ES/BS, eroded surface per bone surface; Oc.S/BS, osteoclast surface per bone surface; MAR, mineral apposition rate. Mean ± SEM, n = 8.

^*P < 0.05 versus Control,

^**P < 0.01 versus Control by non-repeated measures ANOVA with Games-Howell’s honest significance difference post hoc analysis.