Table 3:
Univariate Analysis Predicting OS and DFS
| Variable (n) | OS (%) | DFS (%) | ||||||
|---|---|---|---|---|---|---|---|---|
| 5yr | 10yr | 15yr | P | 5yr | 10yr | 15yr | P | |
| Age | ||||||||
| ≤55 (36) | 89.6 | 68.7 | 29.3 | 0.062 | 65.7 | 46.8 | 31.2 | 0.634 |
| >55 (34) | 66.6 | 49.9 | 0 | 67.0 | 53.6 | 53.6 | ||
| <45 (12) | 100.0 | 62.5 | 20.8 | 0.011 | 60.6 | 40.4 | 40.4 | 0.767 |
| >70 (12) | 35.9 | 35.9 | 35.9 | 63.0 | 63.0 | 63.0 | ||
| Sex | ||||||||
| Female (38) | 88.6 | 65.7 | 39.4 | 0.177 | 74.2 | 52.2 | 52.2 | 0.159 |
| Male (32) | 71.6 | 54.5 | 21.8 | 53.1 | 42.5 | 21.2 | ||
| Smoker | ||||||||
| Never (27) | 85.9 | 61.1 | 61.1 | 0.062 | 71.9 | 53.2 | 35.5 | 0.876 |
| Smoking Hx (35) | 78.9 | 62.1 | 10.4 | 58.8 | 44.1 | 36.7 | ||
| T stage | ||||||||
| 1&2 (34) | 78.8 | 78.8 | 42 | 0.126 | 89.4 | 62.8 | 62.8 | 0.014 |
| 3&4 (29) | 81.1 | 42.6 | 14.2 | 44.3 | 44.3 | 21.4 | ||
| 1 (14) | 92.3 | 92.3 | 30.8 | 0.013 | 92.3 | 42.2 | 42.2 | 0.048 |
| 4 (21) | 83.3 | 26.0 | 0 | 35.6 | 35.6 | 0 | ||
| N stage | ||||||||
| N0 (57) | 79.2 | 63.7 | 29.8 | 0.363 | 70.5 | 53.8 | 41.9 | 0.680 |
| N1 (5) | 80.0 | 53.3 | 53.3 | 66.7 | 66.7 | 66.7 | ||
| Overall stage | ||||||||
| 1&2 (32) | 80.9 | 80.9 | 64.7 | 0.098 | 89.0 | 57.8 | 57.8 | 0.049 |
| 3&4 (31) | 78.0 | 42.9 | 14.3 | 49.2 | 49.2 | 24.6 | ||
| 1 (18) | 83.0 | 83.0 | 27.7 | 0.018 | 93.3 | 48.0 | 48.0 | 0.022 |
| 4 (22) | 74.9 | 23.4 | 0 | 35.6 | 35.6 | 0 | ||
| Location | ||||||||
| Major Gland (25) | 86.7 | 59.6 | 31.9 | 0.312 | 60.9 | 37.2 | 24.8 | 0.233 |
| Other (45) | 69.5 | 69.5 | 23.2 | 73.1 | 73.1 | 73.1 | ||
| Skull Base | ||||||||
| Y (12) | 80.0 | 25.0 | 0 | 0.014 | 41.7 | 41.7 | 41.7 | 0.015 |
| N (51) | 78.8 | 71.7 | 38.4 | 92.8 | 92.8 | 81.2 | ||
| Presentation | ||||||||
| Asymptomatic (25) | 69.3 | 69.3 | 34.6 | 0.575 | 85.0 | 70.8 | 47.2 | 0.200 |
| Symptomatic (45) | 83.2 | 48.9 | 12.2 | 52.8 | 35.2 | 26.4 | ||
| Treatment | ||||||||
| Surg (15) | 92.3 | 92.3 | 92.3 | 0.370 | 80.8 | 80.8 | 80.8 | 0.366 |
| Surg + Rad (41) | 81.7 | 74.9 | 31.2 | 77.8 | 52.0 | 37.1 | ||
| Radiation Dosage | ||||||||
| ≤65(23) | 77.7 | 61.0 | 32.5 | 0.553 | 74.5 | 57.5 | 34.5 | 0.314 |
| >65 (22) | 90.5 | 60.0 | 15.0 | 49.5 | 37.1 | 24.7 | ||
| Margins | ||||||||
| Negative (38)) | 86.3 | 86.3 | 51.8 | 0.003 | 77.9 | 54.6 | 47.7 | 0.902 |
| Positive (17) | 77.8 | 51.9 | 0 | 71.4 | 71.4 | 0 | ||
| Perineural Invasion | ||||||||
| Y (30) | 83.3 | 51.4 | 25.7 | 0.262 | 48.6 | 48.6 | 24.3 | 0.151 |
| N (34) | 92.9 | 82.0 | 32.8 | 81.1 | 48.2 | 48.2 | ||
| Lymphatic Invasion | ||||||||
| Y (8) | 87.5 | 87.5 | 0 | 0.933 | 68.6 | 68.6 | 68.6 | 0.528 |
| N (53) | 80.9 | 65.6 | 30.7 | 69.3 | 45.0 | 32.2 | ||
| Cartilage Invasion | ||||||||
| Y (6) | 80.0 | 80.0 | 0 | 0.528 | 100.0 | 50.0 | 50.0 | 0.539 |
| N (53) | 82.2 | 67.0 | 31.4 | 66.9 | 50.5 | 36.1 | ||
| Metastatic Disease | ||||||||
| Y (16) | 69.9 | 40.8 | 8.2 | 0.002 | ||||
| N (53) | 88.3 | 78.5 | 62.8 | |||||
| Local Recurrence | ||||||||
| Y (11) | 90.0 | 50.6 | 33.8 | 0.695 | ||||
| N (58) | 85.3 | 73.2 | 27.9 | |||||
| Location of Mets | ||||||||
| Lungs (12) | 78.8 | 54.0 | 13.5 | 0.002 | ||||
| Vertebrae (5) | 40.0 | 0 | 0 | |||||
| Time to Recurrence | ||||||||
| <3yrs (11) | 52.6 | 0 | 0 | 0.014 | ||||
| >3yrs (11) | 100.0 | 72.7 | 24.2 | |||||
*
OS = Overall survival, DFS = disease free survival, Y = yes, N = no, Surg = surgery, Rad = radiation