Table 2.

Unadjusted and Adjusted Hazard Ratios for the second opioid related overdose one year after a non-fatal opioid-related overdose.

	Unadjusted Hazard Ratio	95% Confidence Interval		P-value	Adjusted Hazard Ratio	95% Confidence Interval		P-value
Opioid use disorder	2.00	1.58	2.54	<.0001	1.51	1.13	2.01	0.0054
Alcohol use disorder	1.10	0.82	1.47	0.54	0.86	0.61	1.20	0.37
Cannabis use disorder	1.47	1.03	2.10	0.034	1.08	0.74	1.59	0.69
Amphetamine use disorder	1.93	1.33	2.80	0.0006	1.29	0.83	1.99	0.26
Barbiturate use disorder	1.89	1.27	2.82	0.0018	1.11	0.71	1.76	0.64
Cocaine use disorder	1.48	0.88	2.51	0.14	1.02	0.58	1.81	0.95
Hallucinogen use disorder	1.22	0.17	8.89	0.84	--	--	--	--
Multi drug use disorder	2.18	1.40	3.39	0.0006	1.47	0.90	2.40	0.12
Unspecified drug use disorder	1.84	1.42	2.39	<.0001	1.41	1.04	1.91	0.028
Buprenorphine use after index overdose	1.28	0.60	2.72	0.52	0.71	0.30	1.72	0.45
Outpatient substance use service use after index overdose	1.75	1.20	2.55	0.0039	1.54	0.97	2.45	0.068

^*Adjusted for age, race, sex, neighborhood deprivation index, Charlson comorbidity score, anxiety, depression, other mental health disorder (bipolar disorder, developmental disorder, eating disorder, obsessive compulsive disorder, panic disorder, and schizophrenia) daily opioid dose before and after index overdose, dose change, benzodiazepine use before and after index overdose