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Anti-HIV-1 activity and cytotoxicity of 1–8a.
| Compounds | Anti-HIV-1 | Cytotoxicity | Selectivity index |
|---|---|---|---|
| IC50 (μM) | CC50 (μM) | SI | |
| 1 | 0.22 | > 1.8 | > 8.3 |
| 2 | 0.038 | > 1.7 | > 45.5 |
| 3 | 0.31 | > 1.6 | > 4.7 |
| 4 | 4.03 | > 1.8 | > 0.47 |
| 5 | 0.10 | > 1.6 | > 16.1 |
| 6 | > 1.9 | > 1.9 | / |
| 7 | 0.0023 | > 1.7 | > 714 |
| 8 | 0.022 | > 1.8 | > 83.3 |
| AZT | 0.0187 | > 0.37 | > 20 |
The values are means ± SD (n = 3). AZT (zidovudine) was used as a positive control.
NF: not found.
