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ATP-mediated ROS generation regulates IL-6 secretion in a CD73-dependent manner during P. gingivalis infection. Quantitative ELISA measurement of human IL-6 secretion in control GECs treated with the empty vector, and overexpressing GECs incubated with P. gingivalis (MOI 100) for 6 h. Further treatment with ATP [3 mM], a broad-spectrum NADPH oxidase inhibitor DPI [50 μM] and/or ROS scavenger NAC [50 μM] was also performed. N = 6, *p < 0.05, #p < 0.05, ##p < 0.001; Mean ± SEM.
