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[Preprint]. 2020 Mar 27:2020.03.22.002386. Originally published 2020 Mar 22. [Version 3] doi: 10.1101/2020.03.22.002386

Figure 2: Global Analysis of SARS-CoV-2 Protein Interactions.

Figure 2:

(a) Overview of global analyses performed. (b) Gene Ontology (GO) enrichment analysis performed on the human interacting proteins of each viral protein (Methods). The top GO term of each viral protein was selected for visualization. (c) Degree of differential protein expression for the human interacting proteins across human tissues. We obtained protein abundance values for the proteome in 29 human tissues and calculated the median level of abundance for the set of human interacting proteins (top 16 tissues shown). This median value was then compared with the distribution of abundance values for the full proteome in each tissue and summarized as a Z-score from which a p-value was calculated and adjusted for multiple tests. (d) Distribution of correlation of protein level changes during SARS-CoV-2 infection for pairs of viral-human proteins. (e) Significance of the overlap of human interacting proteins between SARS-CoV-2 and other pathogens.