Table 1b.

Expert-identified^a drugs and reagents that modulate SARS-CoV-2 interactors.

Compound Name	Compound Structure	Human Gene/Process	Viral Bait	Drug Status	Activity (nM)
ABBV-74469		BRD2/4	E	Clinical Trial	BRD inhibitor KD = 2.1
dBET6146		BRD2/4	E	Pre-clinical	Degrades BRD proteins IC50 < 10000
MZ1147		BRD2/4	E	Pre-clinical	Degrades BRD proteins KD = 120–228
CPI-0610148		BRD2/4	E	Clinical Trial	BRD2/4 inhibitor BRD2 IC50 = 25 BRD4 IC50 = 18
Sapanisertib61,149		LARP1	N	Clinical Trial	mTOR inhibitor IC50 = 1
Rapamycin61,150		LARP1 FKBP15 FKBP7/10	N Nsp2 Orf8	Approved (Organ rejection)	mTOR inhibitor (with FKBP) IC50 = 2.0
Zotatifin151		EIF4E2/H	Nsp2	Clinical Trial	EIF4a inhibitor IC50 = 1.5
Verdinexor152		NUPs RAE1	Nsp4 Nsp9 Orf6	Clinical Trial	XPO1 nuclear export inhibitor IC50 = 960
Chloroquine153		SIGMAR1	Nsp6	Approved (Malaria)	Sigma 1 binder Ki = 100
Dabrafenib154		NEK9	Nsp9	Approved (Cancer)	NEK9 inhibitor IC50 = 1
WDB002		CEP250	Nsp13	Clinical Trial	CEP250 inhibitor (with FKBP) Kd = 0.29
Sanglifehrin A73		IMPDH2	Nsp14	Pre-clinical	PPIA-IMPDH2 modulator PPIA KD = 0.2 IDPDH2 Binding EC50 = 11.5 (with PPIA)
FK-506155		FKBP7 FKBP10	Orf8	Approved (Organ rejection)	FKBP binder
Pevonedistat68		CUL2	Orf10	Clinical Trial	NEDD8-activating enzyme inhibitor IC50 = 4.7
Ternatin 4156		Translation		Pre-clinical	eEF1A inhibitor IC50 = 71
4E2RCat157		Translation		Pre-clinical	eIF4E/G PPI inhibitor IC50 = 13500
Tomivosertib158,159		Translation		Clinical Trial	MNK1/2 inhibitor IC50 = 2.4
Compound 2160		Viral Transcription		Pre-clinical	Cyclophilin inhibitor KD = 24
Compound 10161		Viral Transcription		Pre-clinical	PI4K-IIIβ inhibitor IC50 = 3.4
PS306130		ER protein processing		Pre-clinical	Sec61 inhibitor IC50 = 20–500
IHVR-19029162,163		ER protein processing		Clinical Trial	Antiviral activity IC50 = 1200
Captopril164		Cell Entry		Approved (Hypertension)	ACE inhibitor Ki = 3
Lisinopril165		Cell Entry		Approved (Hypertension)	ACE inhibitor Ki = 0.27
Camostat166,167		Cell Entry		Approved (Pancreatitis)	Serine protease 1 inhibitor IC50 < 1000
Nafamostat166,168		Cell Entry		Approved (Anticoagulant)	Serine protease 1 inhibitor IC50 = 100
Chloramphenicol169		Mitochondrial ribosome		Approved (Bacterial infection)	Mitochondrial ribosome inhibitor IC50 = 7400
Tigecycline170		Mitochondrial ribosome		Approved (Bacterial infection)	Mitochondrial ribosome inhibitor IC50 = 3300
Linezolid171		Mitochondrial ribosome		Approved (Bacterial infection)	Mitochondrial ribosome inhibitor IC50 = 16000

^a.These molecules derive from expert analysis of human protein interactors of SARS-Co-V2 and reagents and drugs that modulate them; not readily available from the chemoinformatically-searchable literature.