Table 1.

RT-PCR= Reverse Transcription-Polymerase Chain Reaction. CPAP= Continuous Positive Airway Pressure. NIV= Non-Invasive Ventilation. PEEP= Positive End Expiratory Pressure

Inclusion and exclusion criteria
Inclusion criteria
1. Age ≥ 18 y
2. COVID-19 confirmed by a positive RT-PCR test from any specimen or detection of COVID-19 IgM/IgG antibodies
3. Hospital admission with at least one of the following:
- fever: ≥36.6° C from axillary site or ≥37.2° C from oral site or ≥37.6° C from rectal/tympanic site
- respiratory rate ≥ 24 breaths/min
- cough
4. Spontaneous breathing. May be unassisted or assisted by any non-invasive CPAP or NIV with PEEP ≤10 cmH2O
5. Symptoms from ≤8 days
Exclusion criteria
1. Pregnancy
2. Presence of a tracheostomy
3. Treatment with high flow nasal cannula
4. Clinical contraindication to the use of Nitric Oxide, as judged by the attending physician
5. Hospitalized and confirmed diagnosis of COVID-19 for more than 72 hours