Table 1.
Pooled Outcomes of Included Patients
| Outcome | No. of Studies Reporting Variable | No. of Patients Analyzed | Pooled Mean Value or Percentage of Patients (95% CI) | I 2, % | P Value of χ2 | Quality of Evidence (GRADE) |
|---|---|---|---|---|---|---|
| ICU admission | 14 | 2153 | 10.9 (4.5–19.3) | 94.9 | <.0001 | Low |
| Mortality | 23 | 2921 | 4.3 (1.0–9.1) | 94.1 | <.0001 | Low |
| Complications | ||||||
| ARDS | 13 | 2221 | 18.4 (7.4–32.4) | 97.7 | <.0001 | Low |
| Respiratory failure | 8 | 552 | 16.2 (.4–43.3) | 97.2 | <.0001 | Very low |
| Shock | 8 | 1738 | 4.3 (.3–11.3) | 93.6 | <.0001 | Low |
| Coagulopathy | 3 | 1299 | 3.3 (.0–27.7) | 98.3 | <.0001 | Low |
| Acute cardiac injury | 7 | 592 | 7.8 (1.2–18.2) | 90.6 | <.0001 | Low |
| Acute kidney injury | 11 | 1958 | 5.5 (1.1–12.2) | 93.8 | <.0001 | Low |
| Secondary infection | 8 | 588 | 8.7 (4.9–13.3) | 55.7 | .0270 | Low |
| Length of hospital stay, days | 6 | 1531 | 12.2 (10.9–13.4) | 94.3 | <.0001 | Low |
| Duration of viral shedding, days | 5 | 261 | 14.8 (11.5–18.2) | 96.0 | <.0001 | Low |
| Discharged | 22 | 2922 | 37.4 (23.6–52.3) | 98.1 | <.0001 | Low |
Abbreviations: ARDS, acute respiratory distress syndrome; CI, confidence interval; GRADE, Grading of Recommendations Assessment, Development, and Evaluation; ICU, intensive care unit.