Table 5. Adverse events graded according to the Common Terminology Criteria for Adverse Events, version 4.0.

p	Doses	Hematologic adverse event (Grades)								Gastrointestinal adverse event (Grades)
		Anemia		Neutropenia			Thrombocytopenia			Nausea			Vomit			Diarrhea
		1-2	3-4		1-2	3-4		1-2	3-4		1-2	3-4		1-2	3-4		1-2	3-4
1	4
2	2	X			X
3	2	X			X			X			X			X
4	6	X
5	6				X						X						X
6	6	X				X		X
7	6				X
8	6	X
9	6				X
10	6	X			X						X			X			X
11	6		X									X			X
12	3
13	6				X						X			X			X
14	6				X						X						X
15	6				X
16	6	X									X			X
17	6		X			X					X			X
18	2	X									X
19	6				X						X
20	6
21	6	X			X
22	2	X									X			X
23	6	X			X			X
24	3	X
25	6
26	6	X									X
27	6		X		X			X
28	2
29	2				X
30	4		X		X			X			X						X
31	6	X									X
32	6							X			X
33	1	X			X
34	6	X			X			X			X
35	5				X
36	6
37	4	X															X
38	3		X		X			X			X			X
39	6	X			X			X									X
40	1