TABLE 3.
Multivariable cox proportional hazards models for overall survival
| Multivariable analysis | |||
|---|---|---|---|
| Variables | HR | 95%CI | P‐value |
| HCC CD3 (high vs low) | 0.299 | 0.111‐0.807 | .017 |
| ICC‐IM CD3 (high vs low) | 0.344 | 0.134‐0.886 | .027 |
| Peritumor CD3 (high vs low) | – | – | .064 |
| HCC CD8 (high vs low) | 0.234 | 0.092‐0.592 | .002 |
| HCC‐IM CD8 (high vs low) | – | – | .089 |
| ICC‐IM CD8 (high vs low) | 0.375 | 0.142‐0.992 | .048 |
| Peritumor CD8 (high vs low) | 0.254 | 0.092‐0.705 | .009 |
| HCC CD163 (high vs low) | – | – | .545 |
| ICC CD163 (high vs low) | – | – | .381 |
| HCC‐IM CD163 (high vs low) | – | – | .093 |
| HCC Foxp3 (high vs low) | – | – | .218 |
| ICC Foxp3 (high vs low) | 3.426 | 1.328‐8.841 | .011 |
| HCC PD‐1 (high vs low) | – | – | .161 |
| HCC‐IM PD1 (high vs low) | 0.239 | 0.085‐0.672 | .007 |
| ICC‐IM PD1 (high vs low) | – | – | .065 |
| HCC PD‐L1 (positive vs negative) | 3.132 | 1.258‐7.796 | .014 |
| ICC PD‐L1 (positive vs negative) | 3.844 | 1.419‐10.414 | .008 |
| Cluster (2 vs 1) | 4.191 | 1.005‐18.253 | .023 |
| Immune score (high vs low) | 29.266 | 8.157‐105.00 | <.001 |
Abbreviation: IM, invasive margin.