Table 3.

Results of multivariable analysis for overall survival following diagnosis of PTLD

Variable	N	RR of death (95% Confidence Interval)	p-value
PTLD Type			0.098
EBV-positive	222	1.00
EBV-negative	45	1.42 (0.94 – 2.15)
Disease/Conditioning*			0.0002
Malignant disease/MAC+TBI	68	1.00
Malignant disease/MAC no TBI	59	1.42 (0.91 – 2.21	0.128
Malignant disease/RIC+TBI	18	2.06 (1.11 – 3.82)	0.022
Malignant disease/RIC no TBI	37	1.49 (0.91 – 2.44)	0.117
Non-malignant disease +TBI	35	0.42 (0.21 – 0.82)	0.011
Non-malignant disease no TBI	45	0.72 (0.42 – 1.23)	0.234
ATG/CAMPATH received			0.0012
No ATG/CAMPATH	56	1.00
ATG/CAMPATH given	206	2.09 (1.34 – 3.26)

TBI = total body irradiation; MAC: Myeloablative conditioning; NMA: Nonmyeloablative; RIC: Reduced intensity conditioning. ATG=anti-thymocyte globulin

Contrast analyses for the disease/conditioning variable combinations were performed. Only those combinations demonstrating an increased risk of death are reported here: Malignant disease/MAC no TBI vs Non-malignant disease + TBI [RR 3.41 (1.73 – 6.74); p< 0.001]; Malignant disease/MAC no TBI vs Non-malignant disease no TBI [RR 1.96 (1.15 – 3.35); p=0.014]; Malignant disease/RIC+TBI vs Non-malignant disease + TBI [RR 4.96 (2.23 –11.06), p< 0.001]; Malignant disease/RIC+TBI vs Non-malignant disease no TBI [RR 2.85 (1.44 – 5.65), p=0.003]; Malignant disease/RIC no TBI vs Non-malignant disease + TBI [RR 3.59 (1.78 – 7.23), p<0.001]; Malignant disease/RIC no TBI vs Non-malignant disease no TBI [RR 2.06 (1.17 – 3.63), p= 0.013].