Table 3.
Tetrasaccharide Optimization
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|---|---|---|---|---|
| entryd | activation method | scavenger | temp | yield (α-only)a |
| 1 | preactivation | TTBP | −10 °C | 28% |
| 2 | coactivation | TTBP | −10 °C | trace |
| 3b | preactivation | TTBP | −30 °C → −10 °C | 31% |
| 4c | preactivation | TTBP | −10 °C | 30% |
| 5 | preactivation | IBO | −10 °C | trace |
| 6 | preactivation | β-Pinene | −10 °C | trace |
Isolated yield.
4 added at −30 °C.
rxn time 23 h,
1:3 donor/acceptor ratio for all reactions.
