Figure 4.

Predictions of creatinine‐drug interactions for steady‐state or maximal percentage change in serum creatinine (S _Cr) data using the uptake‐OCT2 model (a), and bidirectional‐OCT2 model (b). For studies with repeated administration of perpetrator, percentage change in serum creatinine data at steady‐state were included; for studies with single administration of the perpetrator drug, or for which steady‐state was not reached, the maximal percentage change value was included. Prediction error limits (dashed lines) are described by Eqs. S4–S7. Open circles indicate observed data reported as mean, with the area of the circle proportional to the number of subjects in the relevant clinical study, crosses indicate individual data. Inset figures show the central tendency for the observed data.