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. 2020 May 20;15(5):e0233214. doi: 10.1371/journal.pone.0233214

Table 3. Congo red detection and false-positive rates according to scoring subset, type of preeclampsia, characteristics, preeclampsia risk factors and initial assessments.

Detection rate Statistical significance (P) False-positive rate Statistical significance (P)
Scoring subset
Training 76% (50/66) 0.58 3.1% (22/704) 0.81
Validation 72% (53/74) 2.9% (20/688)
Type of preeclampsia
Severe 83% (84/101) <0.0001 - -
Mild 49% (19/39)
Delivered pre-term 86%(75/87) <0.0001 - -
Term 50% (20/40)
Late pregnancy 70.2% (87/124) <0.05 - -
Mid-pregnancy 100% (16/16)
Early-onset 86.2% (56/65) <0.01 - -
Late-onset 62.7% (47/75)
Admission characteristic*
Pre-term gestation 83%(90/108) <0.0001 3.0% (12/406) 0.93
Term 41%(13/32) 3.0% (30/986)
Symptoms 75% (95/126) 0.14 2.8% (21/741) 0.67
Asymptomatic 57% (8/14) 3.2% (21/651)
Preeclampsia risk factor*
Multiple 88% (7/8) 0.36 14% (3/22) 0.003
Singleton 73% (96/132) 2.8% (39/1370)
Previous preeclampsia 69%(59/86) 0.09 43%(22/51) <0.0001
No previous 81%(44/54) 1.5%(20/1341)
Chronic hypertension 79% (15/19) 0.57 0.0% (0/11) 0.56
None 73% (88/121) 3.0% (42/1381)
Gestational hypertension 79% (11/14) 0.6 6.7% (1/15) 0.41
None 72% (77/107) 3.0% (41/1366)
Pre-gestational diabetes 78% (7/9) 0.77 7.7% (1/13) 0.32
None 73% (96/131) 3.0% (41/1379)
Gestational diabetes 57% (17/30) <0.05 4.0% (7/173) 0.37
None 78% (79/101) 2.8% (34/1206)
Initial assessment
Blood pressure high** 76% (93/123) 0.14 4.9% (3/61) 0.37
Normal 59% (10/17) 2.9% (39/1331)
Proteinuria*** 77% (102/132) x 6.8%(35/515) <0.0001
Normal 13% (1/8) 0.7% (6/828)
Overall 74% (103/140) - 3.0% (42/1392) -

*excluded from proportions: symptoms–missing indication for admission; gestational hypertension–chronic cases; gestational diabetes–pre-gestational cases.

**systolic ≥140 mmHG or diastolic≥90 mmHG.

***dipstick 1+ or more, or concentration ≥300 mg/24hr.