Table 3. Congo red detection and false-positive rates according to scoring subset, type of preeclampsia, characteristics, preeclampsia risk factors and initial assessments.
Detection rate | Statistical significance (P) | False-positive rate | Statistical significance (P) | |
---|---|---|---|---|
Scoring subset | ||||
Training | 76% (50/66) | 0.58 | 3.1% (22/704) | 0.81 |
Validation | 72% (53/74) | 2.9% (20/688) | ||
Type of preeclampsia | ||||
Severe | 83% (84/101) | <0.0001 | - | - |
Mild | 49% (19/39) | |||
Delivered pre-term | 86%(75/87) | <0.0001 | - | - |
Term | 50% (20/40) | |||
Late pregnancy | 70.2% (87/124) | <0.05 | - | - |
Mid-pregnancy | 100% (16/16) | |||
Early-onset | 86.2% (56/65) | <0.01 | - | - |
Late-onset | 62.7% (47/75) | |||
Admission characteristic* | ||||
Pre-term gestation | 83%(90/108) | <0.0001 | 3.0% (12/406) | 0.93 |
Term | 41%(13/32) | 3.0% (30/986) | ||
Symptoms | 75% (95/126) | 0.14 | 2.8% (21/741) | 0.67 |
Asymptomatic | 57% (8/14) | 3.2% (21/651) | ||
Preeclampsia risk factor* | ||||
Multiple | 88% (7/8) | 0.36 | 14% (3/22) | 0.003 |
Singleton | 73% (96/132) | 2.8% (39/1370) | ||
Previous preeclampsia | 69%(59/86) | 0.09 | 43%(22/51) | <0.0001 |
No previous | 81%(44/54) | 1.5%(20/1341) | ||
Chronic hypertension | 79% (15/19) | 0.57 | 0.0% (0/11) | 0.56 |
None | 73% (88/121) | 3.0% (42/1381) | ||
Gestational hypertension | 79% (11/14) | 0.6 | 6.7% (1/15) | 0.41 |
None | 72% (77/107) | 3.0% (41/1366) | ||
Pre-gestational diabetes | 78% (7/9) | 0.77 | 7.7% (1/13) | 0.32 |
None | 73% (96/131) | 3.0% (41/1379) | ||
Gestational diabetes | 57% (17/30) | <0.05 | 4.0% (7/173) | 0.37 |
None | 78% (79/101) | 2.8% (34/1206) | ||
Initial assessment | ||||
Blood pressure high** | 76% (93/123) | 0.14 | 4.9% (3/61) | 0.37 |
Normal | 59% (10/17) | 2.9% (39/1331) | ||
Proteinuria*** | 77% (102/132) | x | 6.8%(35/515) | <0.0001 |
Normal | 13% (1/8) | 0.7% (6/828) | ||
Overall | 74% (103/140) | - | 3.0% (42/1392) | - |
*excluded from proportions: symptoms–missing indication for admission; gestational hypertension–chronic cases; gestational diabetes–pre-gestational cases.
**systolic ≥140 mmHG or diastolic≥90 mmHG.
***dipstick 1+ or more, or concentration ≥300 mg/24hr.