. 2020 May 20;14(5):e0008247. doi: 10.1371/journal.pntd.0008247

Table 2. Association of Allele, Genotype and Carrier frequencies of candidate genes with Leprosy.

SNP	GenotypeN (%)	ControlsN (%)	LeprosyN (%)	OR(95% CI)	P-value	Adjusted OR^a(95% CI)	P-value
rs8057341 *NOD2*	AA	182 (19)	52 (13)	0.56 (0.39–0.80)	0.0017	0.56 (0.37–0.84)	0.0052
	GA	446 (47)	186 (46)	0.82 (0.64–1.05)	0.1220	0.85 (0.63–1.13)	0.2547
	GG^b	328 (34)	167 (41)
	Total	956	406
Allele	A	0.42	0.36	0.76 (0.60–0.96)	0.0243	0.76 (0.58–1.00)	0.0529
Allele	G^b	0.58	0.64
Carriers	AA/GA	628 (66)	239 (59)	0.74 (0.59–0.95)	0.0153	0.76 (0.58–1.00)	0.0512
HWE		0.1886
rs751271 *NOD2*	TT	203 (21.0)	61 (15.0)	0.63 (0.44–0.89)	0.0093	0.67 (0.44–1.01)	0.0561
	GT	468 (49.0)	208 (51.0)	0.93 (0.71–1.20)	0.5738	0.93 (0.68–1.27)	0.6690
	GG^b	286 (30.0)	137 (34.0)
	Total	957	406
Allele	T	0.46	0.41	0.81 (0.64–1.03)	0.0879	0.84 (0.63–1.10)	0.2092
Allele	G^b	0.54	0.59
Carriers	TT/GT	671 (70.0)	269 (66.0)	0.84 (0.65–1.07)	0.1593	0.85 (0.64–1.15)	0.2976
HWE		0.7007
rs2430561 *IFNG*	TT	55 (6.0)	29 (7.0)	1.39 (0.87–2.25)	0.1713	1.67 (0.97–2.89)	0.0641
	AT	341 (35.0)	164 (40.0)	1.27 (0.99–1.62)	0.0531	1.40 (1.06–1.85)	0.0184
	AA	566 (59.0)	214 (53.0)
	Total	962	407
Allele	T	0.23	0.27	1.22 (0.94–1.59)	0.1326	1.34 (0.99–1.81)	0.0584
Allele	A^b	0.77	0.73
Carriers	TT/AT	396 (41)	193 (47)	1.29 (1.02–1.63)	0.0328	1.44 (1.10–1.88)	0.0083
HWE		0.7681
rs9356058 *PACRG/* *PRKN*	CC	89 (9)	43 (11)	1.32 (0.88–1.98)	0.1764	1.36 (0.86–2.15)	0.1878
	TC	382 (41)	193 (48)	1.38 (1.08–1.77)	0.0101	1.27 (0.96–1.69)	0.0880
	TT^b	465 (50)	170 (42)
	Total	936	406
Allele	T	0.70	0.66	0.81 (0.64–1.04)	0.1069	0.83 (0.63–1.10)	0.2011
Allele	C^b	0.30	0.34
Carriers	CC/TC	471 (50)	236 (58)	1.37 (1.08–1.73)	0.0086	1.29 (0.99–1.68)	0.0603
HWE		0.4600
rs1800871 *IL10*	AA	143 (15.0)	60 (15.0)	1.05 (0.73–1.50)	0.7925	0.93 (0.62–1.39)	0.7317
	GA	443 (46.0)	196 (48.0)	1.11 (0.86–1.42)	0.4351	0.94 (0.70–1.25)	0.6551
	GG^b	375 (39.0)	150 (37.0)
	Total	961	406
Allele	A	0.38	0.39	1.04 (0.82–1.32)	0.7315	0.96 (0.73–1.26)	0.7599
Allele	G^b	0.62	0.61
Carriers	AA/AG	586 (61.0)	256 (63.0)	1.09 (0.86–1.39)	0.4709	0.93 (0.71–1.23)	0.6303
HWE		0.5605
rs1800629 *TNF*	AA	7 (1.0)	1 (0.0)	0.33 (0.04–2.66)	0.2954	0.14 (0.01–1.79)	0.1291
	GA	135 (14.0)	50 (12.0)	0.84 (0.60–1.20)	0.3431	0.78 (0.53–1.16)	0.2226
	GG^b	824 (85.0)	361(88.0)
	Total	966	412
Allele	A	0.08	0.06	0.81 (0.51–1.28)	0.3604	0.74 (0.43–1.25	0.2559
Allele	G^b	0.92	0.94
Carriers	AA/GA	142 (15.0)	51 (12.0)	0.82 (0.58–1.15)	0.2562	0.75 (0.51–1.11)	0.1536
HWE		0.7331
rs4833095 *TLR1*	TT	213 (22.0)	102 (25.0)	1.21 (0.87–1.68)	0.2479	1.19 (0.77–1.62)	0.5553
	CT	482 (50.0)	207(50.0)	1.09 (0.82–1.44)	0.5542	1.00 (0.73–1.38)	0.9952
	CC^b	261 (27.0)	103 (25.0)
	Total	956	412
Allele	T	0.47	0.50	1.10 (0.87–1.39)	0.4173	1.06 (0.81–1.37)	0,6841
Allele	C^b	0.53	0.50
Carriers	TT/CT	695 (72.0)	30 (75.0)	1.13 (0.86–1.47)	0.3770	1.04 (0.77–1.40	0.8111
HWE		0.7851
rs2069845 *IL6*	GG	94 (10.0)	38 (9.0)	1.03 (0.68–1.55)	O.8994	1.01 (0.63–1.60)	0.9751
	AG	400 (41.0)	182 (45.0)	1.16 (0.91–1.48)	0.2448	1.11 (0.84–1.47)	0.4676
	AA^b	470 (49.0)	185 (46.0)
	Total	964	405
Allele	G	0.30	0.32	1.06 (0.83–1.37)	0.6208	1.04 (0.78–1.38)	0.7806
Allele	A^b	0.70	0.68
Carriers	GG/AG	494 (51.0)	220 (54.0)	1.13 (0.90–1.43)	0.2985	1.09 (0.83–1.42)	0.5284
HWE		0.5600
rs4942254 *CCDC122/* *LACC1*	CC	126 (13.0)	55 (14.0)	1.09 (0.75–1.57)	0.6548	1.10 (0.72–1.66)	0.6682
	CT	412 (44.0)	187(47.0)	1.13 (0.88–1.45)	0.3412	1.21 (0.91–1.62)	0.1938
	TT^b	396 (42.0)	159 (40.0)
	Total	934	401
Allele	C	0.36	0.37	1.07 (0.84–1.36)	0.6040	1.09 (0.82–1.44)	0.5486
Allele	T^b	0.64	0.63
Carriers	CC/CT	538 (57.0)	242 (61.0)	1.12 (0.88–1.42)	0.3505	1.18 (0.90–1.56)	0.2276
HWE		0.2849
rs7298930 *LRRK2*	AA	125 (13.0)	52 (13.0)	1.00 (0.69–1.46)	0.9830	1.07 (0.70–1.63)	0.7589
	AC	418 (45.0)	195 (48.0)	1.13 (0.88–1.45)	0.3521	1.14 (0.86–1.52)	0.3564
	CC^b	391 (42.0)	162 (40.0)
	Total	934	409
Allele	A	0.36	0.37	1.03 (0.81–1.32)	0.7807	1.06 (0.81–1.40)	0.6604
Allele	C^b	0.64	0.63
Carriers	AA/AC	543 (58.0)	247 (61.0)	1.10 (0.87–1.39)	0.4399	1.13 (0.86–1.47)	0.3863
HWE		0.471
rs3761863 *LRRK2*	TT	218 (23.0)	76 (20.0)	0.78 (0.55–1.09)	0.1412	0.90 (0.61–1.32)	0.5856
	CT	457 (48.0)	189 (49.0)	0.92 (0.70–1.21)	0.5546	0.97 (0.71–1.33)	0.8690
	CC^b	274 (29.0)	123 (32.0)
	Total	949	388
Allele	T	0.47	0.44	0.88 (0.70–1.12)	0.3012	0.95 (0.72–1.24)	0.7067
Allele	C^b	0.53	0.56
Carriers	TT/CT	675 (71.0)	265 (69.0)	0.87 (0.68–1.13)	0.3044	0.95 (0.71–1.27)	0.7352
HWE		0.3334
rs55882956 *TYK2*	AG	2 (0.21)	2 (0.49)	2.36 (0.33 16.8)	0.3903	4.71 (0.61–36.3)	0.1366
	GG^b	960 (99.79)	406 (99.51)
	Total	962	408
Allele	A	0.001	0.002	2.36 (0.15–37.8)	0.5439	4.69 (0.26–83.5)	0.2932
Allele	G^b	0.999	0.998
Carriers	AA/AG	2 (0.21)	2 (0.49)	2.36 (0.33–6.84)	0.3903	4.71 (0.61–36.3)	0.1366
HWE		1
rs76418789 *IL23R*	AG	2 (0.21)	1 (0.25)	1.17 (0.11–12.9)	0.8977	0.95 (0.01–60.5)	0.9804
	GG^b	953 (99.79)	407 (99.75)
	Total	955	408
Allele	A	0.001	0.001	1.17 (0.04–34.9)	0.9276	0.95 (0.0–336.9)	0.9862
Allele	G^b	0.999	0.999
Carriers	AA/AG	2 (0.21)	1 (0.25)	1.17 (0.11–12.9)	0.8977	0.95 (0.01–60.5)	0.9804
HWE		1

Abbreviations: HWE, Hardy–Weinberg equilibrium; OR, odds ratio; SNP, single-nucleotide polymorphism. Bold values express statistically significant results.

^aResults of logistic regression analyses adjusted for the covariates: gender, age and ancestry.

^bBaseline. 95% CI, 95% confidence interval