Fig 4.

(A) Low POLE-dependent cell cycle gene sets (left) and high POLE-dependent MHC class I antigen presentation (right) using gene set enrichment analysis. (B) Grouping of networks based on functionally enriched GO terms and pathways. Functionally grouped networks are linked to their biological function, where only the most significant term in the group is labeled. There was a direct or indirect linkage among POLE, DNA replication, DNA mismatch repair, homologous recombination, DNA ionized radiation-damage and cellular response via ATR and antigen processing and peptide antigen via MHC class I.