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. 2020 May 20;15(5):e0233299. doi: 10.1371/journal.pone.0233299

Table 2. Participants’ clinical, lifestyle and functional status information and the sarcopenia status (n = 506).

Variables Total, n (%) Presence of sarcopenia, n (%) No sarcopenia, n (%)
Presence of sarcopenia 144 (28.5) 362 (71.5)
Duration of diabetes
• <10 years 285 (56.3) 74 (26.0) 211 (74.0)
• ≥10 years 221 (43.7) 70 (31.7) 151 (68.3)
Types of antidiabetic agents (ADA)
• Oral ADA only 326 (64.2) 99 (30.5) 227 (69.5)
• Oral ADA and insulin 153 (30.3) 41 (26.8) 112 (73.2)
• Insulin only 28 (5.5) 4 (14.3) 24 (85.7)
No. of ADA types
• One type 158 (31.2) 39 (24.7) 119 (75.3)
• ≥2 types 348 (68.8) 105 (32.2) 243 (69.8)
Use of insulin sensitizers
• Yes 464 (91.7) 137 (29.5) 327 (70.5)
• No 42 (8.3) 7 (16.7) 35 (83.3)
Use of insulin
• Yes 181 (35.8) 45 (25.9) 136 (75.1)
• No 325 (64.2) 99 (30.5) 226 (69.5)
Use of non-insulin sensitizers
• Yes 258 (51.0) 77 (29.8) 181 (70.2)
• No 248 (49.0) 67 (27.0) 181 (73.0)
Use of sulphonylureas
• Yes 258 (51.0) 77 (29.8) 181 (70.2)
• No 248 (49.0) 67 (27.0) 181 (73.0)
Use of dipeptidylpeptidase-4 inhibitors
• Yes 6 (1.2) 3 (50.0) 3 (50.0)
• No 500 (98.8) 141 (28.2) 359 (71.8)
Use of alpha-glucosidase
• Yes 8 (1.6) 5 (62.5) 3 (37.5)
• No 498 (98.4) 139 (27.9) 359 (72.1)
Presence of diabetes complication
• None 222 (43.8) 63 (28.4) 159 (71.6)
• One complication 185 (36.6) 55 (29.7) 130 (70.3)
• ≥2 complications 99 (19.6) 26 (26.3) 73 (73.7)
Types of diabetes complications (n = 284)
• Retinopathy
    ◦ Yes
    ◦ No
215 (75.7) 62 (28.8) 153 (71.2)
69 (24.3) 19 (27.5) 50 (72.5)
• Nephropathy
    ◦ Yes
    ◦ No
30 (10.6) 10 (33.3) 20 (66.7)
254 (89.4) 71 (28.0) 183 (72.0)
• Neuropathy
    ◦ Yes
    ◦ No
126 (44.4) 29 (23.0) 97 (77.0)
158 (55.6) 52 (32.9) 106 (67.1)
• Peripheral vascular disease
    ◦ Yes
    ◦ No
25 (8.8) 7 (28.0) 18 (72.0)
259 (91.2) 74 (28.6) 185 (71.4)
• Coronary heart disease
    ◦ Yes
    ◦ No
9 (3.2) 3 (33.3) 6 (66.7)
275 (96.8) 78 (28.4) 197 (71.6)
Concurrent hypertension
• Yes 484 (95.7) 134 (27.7) 350 (72.3)
• No 22 (4.3) 10 (45.5) 12 (54.5)
Use of anti-hypertensive agents (n = 484)
• None 21 (4.4) 7 (33.3) 14 (66.7)
• One type 140 (28.9) 42 (30.0) 98 (70.0)
• ≥2 types 323 (66.7) 85 (26.3) 238 (73.7)
Types of anti-hypertensive agents (n = 484)
• Angiotensin-Converting Enzyme Inhibitor
    ◦ Yes
    ◦ No
328 (67.8) 99 (30.2) 229 (69.8)
156 (32.2) 35 (22.4) 121 (77.6)
• Angiotensin II Receptor Blockers
    ◦ Yes
    ◦ No
39 (8.1) 2 (5.1) 37 (94.9)
445 (91.9) 132 (29.7) 313 (70.3)
• Calcium channel blockers
    ◦ Yes
    ◦ No
310 (64.0) 86 (27.7) 224 (72.3)
174 (36.0) 48 (27.6) 126 (72.4)
• Beta blockers
    ◦ Yes
    ◦ No
123 (25.4) 28 (22.8) 95 (77.2)
361 (74.6) 106 (29.4) 255 (70.6)
• Diuretics
    ◦ Yes
    ◦ No
154 (31.8) 39 (25.3) 115 (74.7)
330 (68.2) 95 (28.8) 235 (71.2)
• Alpha blockers
    ◦ Yes
    ◦ No
9 (1.9) 4 (44.4) 5 (55.6)
475 (98.1) 130 (27.4) 345 (72.6)
Concurrent dyslipidaemia
• Yes 485 (95.8) 136 (28.0) 349 (72.0)
• No 21 (4.2) 8 (38.1) 13 (61.9)
Use of lipid lowering agents
• Statins 439 (90.5) 121 (27.6) 318 (72.4)
• Fibrates 3 (0.6) 0 (0.0) 3 (100.0)
• None 43 (8.9) 15 (34.9) 28 (65.1)
No. of medications use
• <5 medications 166 (32.8) 59 (35.5) 107 (64.5)
• ≥5 medications 340 (67.2) 85 (25.0) 255 (75.0)
Current smoking status
• Yes 36 (7.1) 10 (27.8) 26 (72.2)
• No 470 (92.9) 134 (28.5) 336 (71.5)
Alcohol use
• Yes 16 (3.2) 5 (31.3) 11 (68.7)
• No 490 (96.8) 139 (28.4) 351 (71.6)
Complementary and alternative medicine use
• Yes, for diabetes 28 (5.5) 7 (25.0) 21 (75.0)
• Yes, but not for diabetes 51 (10.1) 12 (23.5) 39 (76.5)
• No 427 (84.4) 125 (29.3) 302 (70.7)
Body mass index
• Underweight (<18.5 kg/m2) 12 (2.4) 11 (91.7) 1 (8.3)
• Normal weight (18.5–22.9 kg/m2) 78 (15.4) 57 (73.1) 21 (26.9)
• Overweight (23.0–27.4kg/m2) 198 (38.9) 60 (30.3) 138 (69.7)
• Obese (≥27.5kg/m2) 219 (43.3) 16 (7.3) 203 (92.7)
Waist circumference
• Normal 37 (7.3) 23 (62.2) 14 (37.8)
• Abnormal 469 (92.7) 121 (25.8) 348 (74.2)
Glycated haemoglobin (HbA1c)
• HbA1c ≤7.0% 197 (38.9) 62 (31.5) 135 (68.5)
• HbA1c 7.1–8.0% 97 (19.2) 25 (25.8) 72 (74.2)
• HbA1c >8.0% 212 (41.9) 57 (26.9) 155 (73.1)
Blood pressure (BP)
• Systolic BP (Mean±SD, mmHg) 138.7±19.1 136.89±20.45 139.40±118.42
• Diastolic BP (Mean±SD, mmHg) 73.3±10.3 71.57±10.75 73.94±10.11
Lipid profile
• LDL-C (Mean±SD, mmol/L) 2.7±1.0 2.76±1.05 2.65±1.02
• HDL-C (Mean±SD, mmol/L)
    ◦ Men
    ◦ Women
1.1±0.3 1.16±0.32 1.13±0.28
1.3±0.3 1.28±0.28 1.25±0.27
• TG (Mean±SD, mmol/L) 1.6±0.9 1.64±1.16 1.59±0.92
No. of daily dietary protein intake meals
• None 24 (4.7) 11 (45.8) 13 (54.2)
• 1 meal a day 182 (36.0) 44 (24.2) 138 (75.8)
• 2 meals a day 184 (36.4) 54 (29.3) 130 (70.7)
• 3 meals a day 116 (22.9) 35 (30.2) 81 (69.8)
IPAQ-SF
• Low 256 (50.6) 78 (30.5) 178 (69.5)
• Moderate 154 (30.4) 48 (31.2) 106 (68.8)
• High 96 (19.0) 18 (18.8) 78 (81.2)
Sitting activities
• Median±IQR, minutes/day 120.0±120.0 120.0±120.0 120.0±120.0
Activities of daily livings
• Independent (scores of 5–6) 504 (99.6) 142 (28.1) 362 (71.9)
• Moderately dependent (scores of 3–4) 2 (0.4) 2 (100.0) 0 (0.0)
• Dependent (scores of ≤2) 0 0 (0.0) 0 (0.0)
Instrumental activities of daily livings
• Mean±SD 5.48±1.87 5.70±1.76 4.94±2.03

SD = standard deviation, IPAQ-SF = International Physical Activity Questionnaire Short-Form, LDL-C = low density lipoprotein cholesterol, HDL-C = high density lipoprotein cholesterol and TG = triglyceride