Table 3.
Underlying causes of death grouped by ICD-10 chapter, where cause of death is known
| ICD-10 chapter | Participants with Down syndrome (n=57) |
Participants without Down syndrome (n=205) |
| Certain infectious and parasitic diseases | 5 (8.8%) | <5 |
| Neoplasms | <5 | 33 (16.1%) |
| Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | <5 | <5 |
| Endocrine, nutritional and metabolic diseases | <5 | 8 (3.9%) |
| Mental and behavioural disorders | 5 (8.8%) | <5 |
| Diseases of the nervous system | 7 (12.3%) | 27 (13.2%) |
| Diseases of the eye and adnexa | <5 | <5 |
| Diseases of the ear and mastoid process | <5 | <5 |
| Diseases of the circulatory system | 8 (14.0%) | 42 (20.5%) |
| Diseases of the respiratory system | 8 (14.0%) | 49 (23.9%) |
| Diseases of the digestive system | <5 | 16 (7.8%) |
| Diseases of the skin and subcutaneous tissue | <5 | <5 |
| Diseases of the musculoskeletal system and connective tissue | <5 | <5 |
| Diseases of the genitourinary system | <5 | 5 (2.4%) |
| Pregnancy, childbirth and the puerperium | <5 | <5 |
| Certain conditions originating in the perinatal period | <5 | <5 |
| Congenital malformations, deformations and chromosomal abnormalities | 21 (36.8%) | 6 (2.9%) |
| Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | <5 | <5 |
| External causes of morbidity and mortality | <5 | 7 (3.4%) |
| All deaths | 57 (100%) | 205 (100%) |
ICD-10, International Statistical Classification of Diseases and Related Health Problems, 10th Revision.