Table 5. Multivariate Cox Hazard Proportional Analyses of Progression-Free Survival of First-Line Chemotherapy.
| Variables | GRIm-score |
RMH score |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | ||||
| < 75 | 1 (Reference) | 1 (Reference) | ||
| ≥ 75 | 0.98 (0.65 - 1.47) | 0.91 | 1.00 (0.66 - 1.51) | 1.00 |
| BMI | ||||
| ≥ 18.5 | 1 (Reference) | 1 (Reference) | ||
| < 18.5 | 1.30 (0.76 - 2.22) | 0.34 | 1.21 (0.71 - 2.06) | 0.49 |
| Platinum-based | ||||
| Cisplatin | 1 (Reference) | 1 (Reference) | ||
| Carboplatin | 1.22 (0.73 - 2.01) | 0.45 | 1.08 (0.66 - 1.78) | 0.76 |
| ECOG-PS | ||||
| 0 - 1 | 1 (Reference) | 1 (Reference) | ||
| 2 - 4 | 1.27 (0.84 - 1.92) | 0.26 | 1.33 (0.88 - 2.02) | 0.18 |
| No. of metastases | ||||
| < 3 | 1 (Reference) | |||
| ≥ 3 | 1.60 (1.09 - 2.34) | 0.02 | ||
| GRIm-Score | ||||
| Low (0 - 1) | 1 (Reference) | |||
| High (2 - 3) | 1.13 (0.76 - 1.67) | 0.55 | ||
| NLR | ||||
| < 6 | 1 (Reference) | |||
| ≥ 6 | 0.87 (0.49 - 1.55) | 0.65 | ||
| RMH score | ||||
| Low (0 - 1) | 1 (Reference) | |||
| High (2 - 3) | 1.53 (1.04 - 2.25) | 0.03 | ||
BMI: body mass index; CI: confidence interval; ECOG-PS: Eastern Cooperative Oncology Group performance status; GRIm-score: Gustave Roussy immune score; HR: hazard ratio; NLR: neutrophil-to-lymphocyte ratio; RMH score: Royal Marsden Hospital prognostic score.