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. 2020 May 20;6(21):eaba5996. doi: 10.1126/sciadv.aba5996

Fig. 4. Engineered algae-mediated RT, and PDT can inhibit efficiently the tumor growth (4T1 breast cancer model) after intravenous injection.

Fig. 4

(A) Scheme illustrating treatments. (B) Tumor growth curves of individual mice. (C) Average tumor growth curves of all the groups. Photographs (D) and weight (E) of the tumors collected from the 4T1 tumor–bearing mice of each group (day 12). (F and G) Representative H&E, CD31, Ki-67, and cleaved caspase-3 staining of tumor sections from the tumor tissues in different treatment groups (day 12) and corresponding immunohistochemical index quantitative analysis. Treatments: 1, control; 2, laser alone; 3, RBCM-Algae alone; 4, x-ray irradiation (RT) alone; 5, RT + laser; 6, RBCM-Algae + laser; 7, RBCM-Algae + RT; and 8, RBCM-Algae + RT + laser. Data are means ± SD, n = 5, Student’s two-tailed t test, not significant P ≥ 0.05; *P < 0.05; **P < 0.01; ***P < 0.001.