Table 3.

Pharmacological parameters at human cannabinoid receptors expressed in intact HEK293 cells on forskolin-stimulated cAMP production Values reflect mean ± standard error of at least n=3 experiments performed in duplicate.

	CP55,940	EG-018	THC
hCB1
pEC50±SEM	9.24±0.149	7.51±0.0603***	8.29±0.351*
95% C.I.	(8.82 – 9.65)	(7.25 – 7.77)	(6.78 – 9.8)
EC50 (nM)	0.581	30.9	5.15
95% C.I.	(0.224-1.51)	(17-56.2)	(0.158-166)
Emax±SEM	45.4±1.73%	32.9±2.27%**	41.5±2.3%
95% C.I.	(40.6 – 50.2)	(23.1 – 42.6)	(31.6 – 51.4)
hCB2
pEC50±SEM	8.8±0.0608	6.74±0.292***	7.39±0.144**
95% C.I.	(8.54 – 9.06)	(5.49 – 8)	(6.77 – 8.01)
EC50 (nM)	1.58	182	40.8
95% C.I.	(0.871-2.88)	(10-3240)	(9.77-170)
Emax±SEM	58.8±2.48%	28.1±6.14%**	27.3±3.68%**
95% C.I.	(48.2 – 69.5)	(1.72 – 54.5)	(11.4 – 43.1)

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 vs. CP55,940