. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: Pharmacol Biochem Behav. 2020 Apr 2;193:172918. doi: 10.1016/j.pbb.2020.172918

Table 4.

Pharmacokinetic parameters of EG-018 in rat and human liver microsomes and rat plasma

Parameter	EG-018

Rat liver microsomes
Half life (min)	4.29
CL_{int, micr} (mL/min/mg)	0.16
CL_int (mL/min/kg body wt.)	290.77
CL_H (mL/min/kg body wt.)	46.39
ER	0.84
Human liver microsomes
Half life (min)	2.04
CL_{int, micr} (mL/min/mg)	0.34
CL_int (mL/min/kg body wt.)	393.09
CL_H (mL/min/kg body wt.)	19.03
ER	0.95
Rat Plasma
Half life (h)	2.53
CL/F (mL/min/kg body wt.)	520.93
C_max (ng/mL)	26.01
T_max (h)	2.00
AUC 0-24 h (h.ng/mL)	154.06
AUC 0-∞ (h.ng/mL)	167.92

AUC area under the curve, CL/F observed apparent clearance, CL_H estimated hepatic clearance, CL_int estimated intrinsic clearance, CL_{int, micr} intrinsic microsome clearance, C_max mean maximum observed concentration, ER extraction ratio, T_max mean time of C_max