Table 2.
Genes/gene clusters of heavy metal(loid) resistance (HMR) in Cupriavidus campinensis strain S14E4C
| Genes | Functions | Metal(loid) | Locus tag |
|---|---|---|---|
| czcA# 12 | Cobalt-zinc-cadmium resistance protein | Cd2+, Co2+, Zn2+ | FGG12_RS19525 |
| czcB# 12 | Cobalt-zinc-cadmium efflux RND transporter, membrane fusion protein | Cd2+, Co2+, Zn2+ | FGG12_RS19530 |
| czcC# 12 | Heavy metal RND efflux outer membrane protein | Cd2+, Co2+, Zn2+ | FGG12_RS19535 |
| czcR# 12 | Cobalt-zinc-cadmium resistance protein | Cd2+, Co2+, Zn2+ | FGG12_RS19515 |
| czcE# 12 | CzcE family metal-binding protein | Cd2+, Co2+, Zn2+ | FGG12_RS19505 |
| czcI# 12 | Cobalt-zinc-cadmium regulatory protein | Cd2+, Co2+, Zn2+ | FGG12_RS19540 |
| cadA# 12 | Cadmium-translocating P-type ATPase | Cd2+, Co2+, Zn2+ |
FGG12_RS19635 FGG12_RS19680 |
| cadR# 12 | Cobalt-zinc-cadmium transcriptional regulatory protein | Cd2+, Co2+, Zn2+ | FGG12_RS19620 |
| merA# 12 | Mercuric ion reductase | Hg2+ | FGG12_RS19735 |
| merC# 12 | Mercuric transport protein | Hg2+ | FGG12_RS19740 |
| merP# 12 | Periplasmic mercury (+2) binding protein | Hg2+ | FGG12_RS19745 |
| merT# 12 | Mercuric transport protein | Hg2+ | FGG12_RS19750 |
| merR# 12 | Mercuric resistance operon regulatory protein | Hg2+ | FGG12_RS19755 |
| arsB*1 | Arsenic transporter (efflux pump) | As3+, As5+ | FGG12_RS00815 |
| arsC*1 | Arsenate reductase | As5+ |
FGG12_RS25020 FGG12_RS00810 |
| arsR*1,4,6 | Transcriptional regulator | As |
FGG12_RS00835 FGG12_RS01270 FGG12_RS11920 FGG12_RS09700 |
| arsH*1 | Organoarsenical detoxification | As3+ | FGG12_RS00805 |
| chrA32 | Chromate transport protein (RND efflux) | Cr6+ | FGG12_RS28790 |
| copC#*1, 12 | Copper resistance protein | Cu2+ |
FGG12_RS19835 FGG12_RS03095 |
| copD#* 1, 12, 16 | Copper resistance protein | Cu2+ |
FGG12_RS19840 FGG12_RS23205 FGG12_RS03090 |
| copG# 12 | CopG family transcriptional regulator | FGG12_RS19865 | |
| copQ 2,3,5 | Copper resistance protein | Cu2+ |
FGG12_RS04775 FGG12_RS07055 FGG12_RS08045 FGG12_RS10890 |
| copK# 12 | Periplasmic Cu(I)/Cu(II)-binding protein CopK | FGG12_RS19800 | |
| cusA2,3,5,8 | Cation efflux system protein | Cu2+, Ag+ |
FGG12_RS04660 FGG12_RS15640 FGG12_RS08075 FGG12_RS11275 |
| cutA 13 | Periplasmic divalent cation tolerance protein | Cu2+ | FGG12_RS20295 |
| cueR12,23 | Cu(I)-responsive transcriptional regulator | Cu+ |
FGG12_RS19675 FGG12_RS26765 |
| hupE17 | UreJ family metal transporter | Ni2+ | FGG12_RS23365 |
| corA 4,13,16,22 | Magnesium and cobalt transport protein | Mg2+, Co2+ |
FGG12_RS23065 FGG12_RS20305 FGG12_RS26445 FGG12_RS09045 |
| mgtC 2,4,12 | Mg2+ transport ATPase protein | Mg2+ |
FGG12_RS19555 FGG12_RS04485 FGG12_RS09090 |
Some genes exist in multiple copies and locations were shown on each cell
#Genes located on plasmid
*Genes located on chromosome; Numbers depict relevant contigs; Locus tags are from NCBI annotation